Having been active since 2006, the KIC Laboratory covers the scientific fields of Intelligent Informatics as well as the fields of Geoinformatics and Environmental Informatics. The main research activities of the Laboratory focus on Flexible Informatics, Computational Intelligence, Biomedical Signal Processing, Fault Detection in Electromechanical Systems, Geoinformatics and Environmental Informatics, Intelligent Systems, and Personnel and Task Scheduling. Additionally, the Laboratory has participated in the implementation of research and co-financed development projects within the framework of programs such as FP7 Marie-Curie, Erasmus+, INTERREG, South East Europe, IPA Adriatic, Greece-Italy 2007-2014, Greece-Czech Republic, Lifelong Learning, with activities that can be summarized as follows: Design & Development of Advanced Information Systems, Design & Development of Decision Support Systems, Geoinformatics & Environment, Design & Development of Applications for Cultural/Tourism Content Display, Innovation & Business, and Education, Training, Lifelong Learning & Consulting. Thanks to the active engagement of its members, the Laboratory has managed to develop collaborations with academic institutions, research centers, technological institutes, public and private organizations, and industry stakeholders in Greece, Europe, Russia, China, the USA, and Canada.